Survival in patients with non-small cell lung cancer treated with second-line docetaxel

Authors

  • Diana Laura Páramo González Instituto de Oncología y Radiobiología https://orcid.org/0000-0002-1325-4849
  • Yoanna Ivette Flores Vega Instituto de Oncología y Radiobiología
  • Angeles Noa Rodríguez Hospital general Enrique Cabrera
  • Sofia de la Caridad Alsina Sarmiento Instituto de Oncología y Radiobiología
  • Luis Enrique Alsina Tul Instituto de Oncología y Radiobiología
  • Dayana Pérez Méderos Instituto de Oncología y Radiobiología
  • Angel Rene Elejalde Larrinaga Instituto de Oncología y Radiobiología
  • Iris Beatriz Inguanzo Valdéz Instituto de Oncología y Radiobiología
  • Janet Lamadrid García Instituto de Oncología y Radiobiología
  • Iniris Greca Santana Alvarez Instituto de Oncología y Radiobiología
  • Anibal Tabio Lage Instituto de Oncología y Radiobiología
  • Gissell Gómez Trueba Instituto de Oncología y Radiobiología
  • Juan Carlos Collado Otero Instituto de Oncología y Radiobiología
  • Elías Gracia Medina Instituto de Oncología y Radiobiología

Abstract

Background: Lung cancer is the leading cause of death from cancer. Approximately, 85 % of patients are classified as non-small cell lung cancer, more than 50 % are diagnosed in advanced stages where the therapeutic pillar is systemic treatment. With conventional chemotherapy, approximately 33 % are alive one year after diagnosis, and in the scenario of relapse and/or progression, chemotherapy with Docetaxel is a valid treatment option.

Objective: Estimating survival in patients with non-small cell lung cancer treated with second-line docetaxel at the Institute of Oncology and Radiobiology

Methods: A descriptive, retrospective study was carried out with the objective of describing patients with NSCLC treated with second-line with docetaxel at the INOR from January 2018 to December 2020. The clinical and pathological characteristics were described, as well as the therapy received and its results. Survival was related to clinical variables.

Results: A total of 82 patients were analyzed, 58,5 % were male, and 43,9 % were between 60-69 years old. The predominant histology was Adenocarcinoma (48,1 %). Stage IV at diagnosis was the most frequent (41,5 %) and 67,1 % of patients presented ECOG 1 at relapse and/or progression. 65,9 % met the therapeutic standard of 4-6 cycles and 29,3 % had an objective response. The overall survival (OS) rate was 22 % at 18 months, with a median overall survival of 9 months (95 % CI 6,6 – 11,4) and was statistically higher in those who received 4 -6 cycles.

Conclusion: Overall survival was similar to that reported internationally. This result could be a reference for future studies to be carried out in the country.

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Author Biographies

Diana Laura Páramo González, Instituto de Oncología y Radiobiología

Departamento de Oncología Médica

Instituto de Oncología y Radiobiología

Yoanna Ivette Flores Vega, Instituto de Oncología y Radiobiología

Servicio de Oncología Médica

Angeles Noa Rodríguez, Hospital general Enrique Cabrera

Servicio de Oncología Médica

Sofia de la Caridad Alsina Sarmiento, Instituto de Oncología y Radiobiología

Servicio de Oncología Médica

Luis Enrique Alsina Tul, Instituto de Oncología y Radiobiología

Servicio de Oncología Médica

Dayana Pérez Méderos, Instituto de Oncología y Radiobiología

Servicio de Oncología Médica

Angel Rene Elejalde Larrinaga, Instituto de Oncología y Radiobiología

Departamento de Neumología

Iris Beatriz Inguanzo Valdéz, Instituto de Oncología y Radiobiología

Departamento de Radioterapia

Janet Lamadrid García, Instituto de Oncología y Radiobiología

Departamento de Anatomía Patólogica

Iniris Greca Santana Alvarez, Instituto de Oncología y Radiobiología

Departamento de Imagenología

Anibal Tabio Lage, Instituto de Oncología y Radiobiología

Servicio de Cirugía Explácnica

Gissell Gómez Trueba, Instituto de Oncología y Radiobiología

Servicio de Cirugía Explácnica

Juan Carlos Collado Otero, Instituto de Oncología y Radiobiología

Servicio de Cirugía Explácnica

Elías Gracia Medina, Instituto de Oncología y Radiobiología

Servicio de Oncología Médica

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2025-06-16

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Páramo González DL, Flores Vega YI, Noa Rodríguez A, Alsina Sarmiento S de la C, Alsina Tul LE, Pérez Méderos D, et al. Survival in patients with non-small cell lung cancer treated with second-line docetaxel. Rev Cub Oncol [Internet]. 2025 Jun. 16 [cited 2025 Aug. 23];22. Available from: https://revoncologia.sld.cu/index.php/onc/article/view/40295

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